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La PDE5 è la fosfodiesterasi predominante nei vasi polmonari. L’inibizione della PDE5 da parte di tadalafil aumenta le concentrazioni della cGMP determinando un rilassamento della muscolatura liscia dei vasi polmonari e una vasodilatazione del letto vascolare polmonare.
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Sovradosaggio: Dosi singole fino a five hundred mg sono state somministrate a soggetti sani, e dosi a number of giornaliere fino a one hundred mg sono condition somministrate a pazienti. Gli eventi avversi sono stati simili a quelli osservati a dosaggi più bassi.
Cialis è inoltre controindicato nei pazienti che hanno perso la vista da un occhio a causa della neuropatia ottica ischemica anteriore non-arteritica (NAION), indipendentemente dal fatto che questo evento sia o meno correlato al precedente impiego di un inibitore della PDE5.
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Le cellule del corpo cavernoso del pene producono ossido nitrico (NO) che, durante l’eccitazione sessuale, stimola la formazione di GMP ciclico. Un aumento di GMP ciclico nella muscolatura liscia provoca un rilassamento delle fibre piç muscolari con conseguente vasodilatazione.
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